As someone who's commuted at 70-80MPH on the highway in 17 degree F weather, I can tell you that it is possible, but it's far from comfortable, and very dangerous.
Let me count the ways:
1) Motorcycle tires have to be warm to stick to the road, in cold weather, they might warm up by the time you get to your destination.
2) One look at a wind-chill chart and you'll realize that you're going to get frostbite unless your entire outfit is wind-proof and warm
3) As if snow and ice aren't bad enough (as in, you'll crash if you hit any, even at parking lot speeds), in most places you also have to deal with salt, gravel and all sorts of other debris on the road (you'll crash if you hit that too)
4) Unless you live someplace where everyone is an expert winter driver, you're going to also have to deal with cars sliding into your lane spinning 360s in front of you, crashing into the ditch and blasting the roadway with powder, speeding SUVs with snow-tires blasting past you at 120MPH etc.
In summary, the only way it's really possible is if there's a perfectly straight, plowed, dry-ass road between you and work (i.e. a well used highway). This includes all side streets and off-ramps too, as it only takes one patch of ice on the road to make the route impassable.
